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KMID : 0043319860090030175
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Archives of Pharmacal Research
1986 Volume.9 No. 3 p.175 ~ p.181
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Effects of Some Organophosphate Pesticides on the Murine Immune System following Subchronic Exposure (I)
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Moon CK
Yun YP/Lee SH/Lee YS
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Abstract
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Four technical grade organophosphate pesticides (Fenitrothion, Fenthion, Diazinon and EPN) were investigated for their effects on the murine immune function. Among the immunotoxicological assay parameters of NIEHS, humoral immune parameter and pathotoxicological indicators were examined in this study. Subchronic exposure of rodents to these pesticides resulted in marked suppression of humoral immune function and moderate histological changes of lymphoid organ without any significant alterations of clinical status.
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